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  • Nursing
  • Advanced Practice Nursing
Hours: 10 Contact Hours (10 Pharm Hours)
  • C. Michael White, PharmD, FCP, FCCP
  • Diana M. Sobieraj, PharmD, BCPS
  • William L. Baker, PharmD, FCCP, FACC, BCPS-AQ Cardiology
  • Leanne Henry Fowler, DNP, AGACNP-BC, CCRN, CNE
Peer Reviewer(s):
  • Abir Kanaan, PharmD, RPh
  • Jason Cross, PharmD
  • Amy Drew, PharmD, BCPS
Item#: N1752
Contents: 1 Course Book (110 pages)
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Anticoagulant, Antiplatelet, and Thrombolytic Therapies: Implications for Advanced Practice Nursing

Price $33.95
Item # N1752
High-Level Content
When available, the Online Course format is included with the hard copy, eBook, or audio book formats!

Release Date: December 27, 2016

Expiration Date: December 31, 2019


Cardiovascular disease (CVD) is the leading cause of death in the United States. Despite a decline in the death rate in 2013, nearly 1 in 3 deaths were attributed to CVD. Anticoagulant, antiplatelet, and thrombolytic medications are commonly utilized in the prevention and management of many common medical conditions, including cardiovascular disease (stable and unstable angina), ST-elevation myocardial infarction, percutaneous coronary interventions that include stent placement, cardiac dysrhythmias (atrial fibrillation), acute arterial occlusion, peripheral arterial disease, deep vein thrombosis, pulmonary embolism, and ischemic stroke.  

Evidence-based nursing practice requires that nurses have the necessary knowledge base to assure competent and safe nursing care. The Joint Commission (2012) addresses the issue of patient safety within the context of anticoagulation therapy in National Patient Safety Goal 03.05.01, which advises healthcare providers to “reduce the likelihood of patient harm associated with the use of anticoagulant therapy.”

This course provides information on oral anticoagulants, with an emphasis on the novel oral anticoagulants, parenteral anticoagulants, antiplatelets, and thrombolytics. Their indications for treatment of cardiovascular disorders including atrial fibrillation, venous thromboembolism, acute coronary syndrome, heparin induced thrombocytopenia, acute ischemic stroke, acute myocardial infarctions and acute pulmonary embolism is review. In addition, monitoring guidelines and patient counseling is discussed.  The need for healthcare providers to understand the pharmacokinetics, pharmacodynamics, and pharmacotherapeutic considerations is imperative to achieve optimal patient outcomes.


This course should not be taken in conjunction with N1712 - Parenteral Anticoagulants: Implications for Patient Management, N1718 - Oral Anticoagulant Therapy: Implications for Patient Management, N1743 - Antiplatelet Therapy: Implications for Advanced Practice Nursing, or N1749 - Thrombolytic Therapy: Implications for Advanced Practice Nursing.

Kentucky APRNs - fulfills pharmacology requirement


Course Objectives

  • Describe the pharmacokinetics and pharmacodynamics of the novel oral anticoagulants and be able to identify the most appropriate and safest agent for the management of thrombotic conditions.
  • Differentiate between the use of current parenteral anticoagulants in the acute care setting for patients with acute coronary syndrome, treatment and prevention of venous thromboembolism, and heparin induced thrombocytopenia to achieve to achieve optimal outcomes.
  • Identify the appropriate antiplatelet medications and monitoring through increased knowledge of platelet aggregation and understanding of the pharmacokinetics and pharmacodynamics of antiplatelet agents.
  • Explain the difference in the pharmacokinetics and pharmacodynamics of thrombolytic agents to achieve optimal outcomes for patients diagnosed with acute ischemic stroke, myocardial infarction, and pulmonary embolism.

C. Michael White, PharmD, FCP, FCCP, is professor and chair of the University of Connecticut School of Pharmacy’s Department of Pharmacy Practice in Storrs, Connecticut, and codirector of the Health Outcomes, Policy, and Evidence Synthesis research group at University of Connecticut (UConn) and Hartford Hospital in Hartford, Connecticut, which houses one of only 13 Agency for Healthcare Research and Quality-Designated Evidence-Based Practice Centers. Dr. White received his BS in Pharmacy and Doctor of Pharmacy degrees from the Albany College of Pharmacy in Albany, New York, and completed a cardiovascular clinical pharmacology fellowship at Hartford Hospital in Hartford, Connecticut. Dr. White has published more than 150 peer-reviewed articles, including publications in JAMA, Annals of Internal Medicine, Circulation, and Lancet. His research has been selected for the American Society of Health Systems Pharmacists Drug Therapy Research Award and the American Association of Colleges of Pharmacy Lyman Award. He is an American College of Clinical Pharmacy Young Investigator of the Year recipient and fellow of the American College of Clinical Pharmacologists and American College of Clinical Pharmacists. He is a contributing editor to the Annals of Pharmacotherapy, is on the editorial board for Pharmacy Practice News, and hosts a once-weekly show called “Ask the Pharmacist” on FOX61 in Hartford, Connecticut.

Diana M. Sobieraj, PharmD, BCPS, earned her Doctor of Pharmacy degree from the University of Rhode Island and subsequently completed a pharmacy practice residency at Hartford Hospital/The University of Connecticut School of Pharmacy. After her training, Dr. Sobieraj joined the faculty at UCONN School of Pharmacy, where she has worked for the past 8 years. Currently, Dr. Sobieraj is an Assistant Professor in the Department of Pharmacy Practice in the tenure track. Her scholarly interests focus on comparative effectiveness and health outcomes research of anticoagulants and the treatment and prevention of thrombosis. Dr. Sobieraj has more than 40 publications in the peer-reviewed literature, including journals such as Annals of Internal Medicine, Journal of the American Geriatrics Society, International Journal of Cardiology, and Thrombosis Research. Dr. Sobieraj is a member of the American College of Clinical Pharmacy, the current Secretary/Treasurer of the American College of Clinical Pharmacy Health Outcomes PRN, and a member of the Community Advisory Panel of the American College of Clinical Pharmacy Practice-Based Research Network.

William L. Baker, PharmD, FCCP, FACC, BCPS-AQ Cardiology, is an Assistant Professor of Pharmacy Practice at the University of Connecticut (UConn) School of Pharmacy in Storrs, Connecticut. Dr. Baker received his BS in Pharmacy Studies and Doctor of Pharmacy (PharmD) degrees from the UConn School of Pharmacy in 2000 and 2002, respectively. After being in clinical practice for a number of years, he completed a 2-year cardiovascular pharmacology and outcomes research fellowship at Hartford Hospital in Hartford, Connecticut (2006-2008). He has been on faculty with the UConn School of Pharmacy since 2009. Dr. Baker is a member of a number of pharmacy and cardiology organizations, including the American College of Clinical Pharmacy, American Heart Association, and American College of Cardiology. His clinical experience has focused on caring for adult patients with advanced heart disease who require mechanical therapies or cardiac transplantation. He is the author of more than 100 peer-reviewed publications and frequently presents his research at national/ international pharmacy and cardiology conferences. Dr. Baker teaches cardiovascular pharmacology and therapeutics in the UConn School of Pharmacy and holds adjunct appointments as Assistant Professor with both the UConn School of Medicine and UConn Graduate School.

Leanne Henry Fowler, DNP, AGACNP-BC, CCRN, CNE, graduated with a baccalaureate of science in nursing degree from Southern University in Baton Rouge, Louisiana, and a doctorate in nursing practice (DNP) specializing in nursing education and as an adult/gerontology acute care nurse practitioner from the University of South Alabama in Mobile. She conducted a successful quality improvement project for her DNP project titled Preventing Oversedation in the Mechanically Ventilated Adult via Interprofessional Implementation of the RASS Tool. She has 15 years of critical care nursing experience, 8 years of nursing education experience, 2 years as a board-certified adult/gerontology acute care nurse practitioner in hospital medicine, and 6 months in infectious diseases. She is ranked as an instructor at the LSU Health Sciences Center’s School of Nursing, where she is the course coordinator for the critical care course in the baccalaureate program and the BSN to DNP academic coordinator for the Adult-Gerontology Acute and Emergency Care Nurse Practitioner concentration. She is an active member in several professional organizations, including the American Association of Nurse Practitioners (nationally, as well as in the state and local chapters), American Association of Critical-Care Nurses (nationally, as well as the local chapter), Society of Critical Care Medicine (nationally, as well as the regional chapter), National League for Nursing, National Organization of Nurse Practitioner Faculty, and the Epsilon Nu chapter of Sigma Theta Tau.

Abir Kanaan, PharmD, RPh, is an associate professor of pharmacy practice at Massachusetts College of Pharmacy and Health Sciences (MCPHS) University. She joined the university in 2005, after completing a postgraduate pharmacy practice residency at University of Massachusetts Memorial Medical Center in Worcester, Massachusetts. Dr. Kanaan also holds an adjunct faculty position in the Department of Medicine at the University of Massachusetts Medical School. She is affiliated with the Meyers Primary Care Institute, where she is involved in several research projects pertaining to medication safety in the outpatient setting.

Dr. Kanaan serves as a co-director and preceptor for the pharmacy fellowship program in Medication Safety, Quality and Informatics at Saint Vincent Hospital in Worcester. Dr. Kanaan is also the Postgraduate Education Committee Program Coordinator for the Worcester and Manchester campuses at MCPHS University. Dr. Kanaan’s practice site is Saint Vincent Hospital in the Coronary Intensive Care unit. She started and currently leads the hospital’s anticoagulation monitoring program.

Jason Cross, PharmD, is an Associate Professor of Pharmacy Practice at MCPHS University (Worcester/Manchester Campus). He completed his PharmD at the University of Rhode Island College of Pharmacy in 2001 and then completed a pharmacy practice residency at UMass Medical School/UMass Memorial Medical Center. Since 2002, he has been a faculty member at MCPHS, where he has maintained practice sites in ambulatory care, critical care, and adult internal medicine. Dr. Cross facilitates several courses within the Doctor of Pharmacy, Master of Physician Assistant, and Doctor of Physical Therapy programs. Dr. Cross currently practices adult internal medicine at Baystate Medical Center, Springfield, Massachusetts, and is the assistant director of the Pharmacy Practice Residency.

Amy Drew, PharmD, BCPS, is an Associate Professor with the Division of Pharmacy Practice, Preceptor for PGY 1 Pharmacy Residency Program at Mercy Hospital/Saint Louis College of Pharmacy in Saint Louis, Missouri, and Clinical Pharmacist in Ambulatory Care at Mercy Clinic Family Medicine in Saint Louis, Missouri. Dr. Drew earned her earned her BS in Biology from University of Illinois at Urbana-Champaign and her PharmD from Midwestern University in Glendale, Arizona. She completed her residency training at the John Cochran VA Medical Center in St. Louis, Missouri. Since then, she has had a full-time faculty appointment with responsibilities in teaching, lecture coordination, resident and student precepting, research, and clinical practice. Her practice and scholarship have focused primarily in the areas of anticoagulation, diabetes, osteoporosis, and teaching and learning within the advanced practice setting. She is an active member of the American College of Clinical Pharmacy and American Society of Health-Systems Pharmacists, and she is board certified in pharmacotherapy specialty.

  • Courses must be completed on or before the expiration date noted in the course description above.
  • You must score 75% or higher on the final exam and complete the course evaluation to pass this course and receive a certificate of completion.
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  • All persons involved in the planning and development of this course have disclosed no relevant financial relationships or other conflicts of interest related to the course content.