Disciplines:
  • Nursing
  • Advanced Practice Nursing
  • Psychiatric Technicians
Hours: 4 Contact Hours
(4 pharm hours)
Author(s): Cathy Cooper, EdD, MSN, RN, CNE
Peer Reviewer(s):
  • Mattia M. Migliore, RPh, PhD
  • Barbara LeDuc, RN, PhD
Item#: N1589
Contents: 1 Course Book (56 pages)

Anticoagulant, Antiplatelet, and Thrombolytic Medications: Nursing Implications for Patient Management



Price $19.95
Item # N1589
When available, the Online Course format is included with the hard copy, eBook, or audio book formats!

Note: This course must be completed by 12/31/16. Contact hours will not be awarded beyond this date.

Anticoagulant, antiplatelet, and thrombolytic medications are commonly used in the prevention and management of many common medical conditions, including cardiovascular disease (stable and unstable angina), ST-elevation myocardial infarction, percutaneous coronary interventions that include stent placement, cardiac dysrhythmias (atrial fibrillation), acute arterial occlusion, peripheral arterial disease, deep vein thrombosis, pulmonary embolism, and ischemic stroke. 

This course describes the nursing implications in managing care of patients receiving these medications, including strategies to enhance therapeutic effects and minimize the risk of adverse effects. This course begins with an overview of hemostasis, with discussion of the clotting cascade, and then describes the regulation of hemostasis and the normal physiology of clot removal. The discussion then turns to anticoagulant medications, which work by preventing clotting factor synthesis or clotting factor activity. They include vitamin K antagonists, factor Xa and thrombin inhibitors, direct thrombin inhibitors, and medications that inhibit selective clotting factor (factor Xa) activity. Antiplatelet medications, such as cyclooxygenase inhibitors, thienopyridines (adenosine diphosphate [ADP] receptor blockers), phosphodiesterase inhibitors, and glycoprotein IIb/IIIa inhibitors, prevent the formation of new blood clots or the extension of existing blood clots. Thrombolytic (also known as fibrinolytic) medications act directly to dissolve existing blood clots and are used for the acute treatment of thrombosis. 

This course is designed for nurses who care for patients receiving the described medications. Advanced practice nurse prescribers may benefit from this course as a review of medications and potential drug–drug interactions.

Course Objectives
  • Describe the normal physiologic process of hemostasis.
  • Discuss the actions of anticoagulant antiplatelet and thrombolytic medications.
  • Identify potential complications associated with administration of anticoagulant antiplatelet and thrombolytic medications.
  • Discuss nursing implications that contribute to safe administration of anticoagulant antiplatelet and thrombolytic medications.
  • Describe key points to include in teaching patients and families about anticoagulant antiplatelet and thrombolytic medications
Cathy Cooper, EdD, MSN, RN, CNE, is an Associate Professor of Nursing and graduate faculty member in the School of Nursing at Middle Tennessee State University Murfreesboro, Tennessee. Dr. Cooper received her BSN degree from Indiana State University in Terre Haute Indiana; her MSN from Indiana University-Purdue University in Indianapolis Indiana and her Doctor of Education in the field of Educational Leadership from the University of St. Thomas in Minneapolis, Minnesota. She is certified as a Nurse Educator through the National League for Nursing. 

Dr. Cooper is a member of the American Association of Critical Care Nurses Sigma Theta Tau International Nursing honor society and the Tennessee Nurses Association. Her clinical experience has focused on caring for adult patients experiencing life threatening critical illnesses including myocardial infarction acute respiratory failure and undergoing open heart or vascular surgery. She was involved in establishing a nurse managed anticoagulation service at a hospital in northwestern Wisconsin where she developed and presented a program module on hemostasis to nurses. Dr. Cooper has presented at both local and national nursing conferences and is a published author. Her current research interests include women and heart disease and strategies to improve efficacy in the management of hypertension. Dr. Cooper has taught a variety of nursing courses including fundamentals theoretical foundations critical care management and leadership and end-of-life care. She currently teaches adult medical-surgical nursing to upper division nursing students in a bachelor of science nursing program in Murfreesboro, Tennessee.

Mattia M. Migliore, RPh, PhD has 10 years of experience working at the Brigham and Women’s Hospital AnticoagulationService. She holds a Bachelor of Science in Pharmacy from Massachusetts College of Pharmacy and Health Sciences (MCPHS; 1997), a Master of Pharmaceutical Sciences from Northeastern University (2002), and a PhD in Pharmacology and Nanomedicine from Northeastern University (2008). Dr. Migliore has been an assistant professor in pharmacology and toxicology for the past 4 years.

Barbara LeDuc, RN, PhD has been associate professor of pharmacology at MCPHS for 16 years, having taught pharmacology to nursing, physician assistant, pharmacy, and graduate students. She graduated from The Faulkner Hospital School of Nursing in 1965 and, in 1993, received her PhD in Biochemistry from The Sackler School of Graduate Biomedical Sciences at Tufts University. Her research interests include drug metabolism and drug-drug interactions.

  • Contact hours will be awarded for up to one (1) year from the date the course is ordered.
  • You must score 75% or higher on the final exam and complete the course evaluation to pass this course and receive a certificate of completion.
  • Through our review processes, Western Schools ensures that this course content is presented in a balanced, unbiased manner and is free from commercial influence. It is Western Schools’ policy not to accept commercial support.
  • All persons involved in the planning and development of this course have disclosed no relevant financial relationships or other conflicts of interest related to the course content.